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During pregnancythis medication should be used only when clearly needed. Get medical help right away if you have any of the following symptoms: Bowel problems including constipation or stomach pain. Treatment The treatment of overdosage with promethazine, phenylephrine and codeine is essentially symptomatic and supportive.
Many people using this medication do not have serious side effects. Phenylephrine Central Nervous System: Because of similar pharmacologic properties, it is reasonable to expect similar risk with concomitant use of opioid cough medications and benzodiazepines, other CNS depressants, or alcohol. Examples include azole antifungals such as ketoconazolebupropionfluoxetinemacrolide antibiotics such as erythromycinHIV medications such as ritonavirparoxetine, quinidinerifamycins such as rifabutinrifampincertain drugs used to treat seizures such as carbamazepinephenytoinamong others.
Infants and children are believed to be relatively more sensitive to opiates on a body-weight basis. Benzodiazepine drugs are used to treat many health problems like anxiety, trouble sleeping, or seizures. A rise in temperature or pulmonary complications may signal the need for institution of antibiotic therapy. This drug may make you dizzy or drowsy. Phenylephrine should not be used in patients known to be hypersensitive to the drug or in those receiving a monoamine oxidase inhibitor MAOI.
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Discuss the risks and benefits with your doctor before breast-feeding.
What is codeine and phenylephrine?
Codeine is changed into a strong narcotic drug morphine in your body. Taking codeine and phenylephrine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Concomitant use of opioids, including promethazine HCl, phenylephrine HCl and codeine phosphate syrup, with benzodiazepines, or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.
Store at room temperature away from light and moisture. Codeine Central Nervous System: Histamine release may also produce dilation of cutaneous blood vessels, with resultant flushing of the face and neck, pruritus, and sweating. It is used in preference to morphine, because side effects are infrequent at the usual antitussive dose of codeine.
In some people, codeine breaks down rapidly in the liver and reaches higher than normal levels in the body. Promethazine is contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines.
Because of this risk, patients should avoid concomitant use of promethazine HCl, phenylephrine HCl and codeine phosphate syrup with benzodiazepines or other CNS depressants, including alcohol. These may be symptoms of a serious medical problem and should be checked by a doctor.