For injection the available combinations are: Skin and subcutaneous tissue disorders There have been rare reports of rashes, including pruritus, urticaria and, very rarely, erythema multiforme, Stevens- Johnson syndrome and toxic epidermal necrolysis.
Subscribe to receive email notifications whenever new articles are published. Scientists at Chugai Pharmaceuticals discovered an erythromycin-derived motilin agonist called mitemcinal that is believed to have strong prokinetic properties similar to erythromycin but lacking antibiotic properties. It may be useful in treating gastroparesis due to this promotility effect. Mechanism s of resistance Several mechanisms of acquired resistance to erythromycin have been described, the most common being plasmid mediated ability to methylate ribosomal RNA, resulting in decreased binding of the antimicrobial.
Retrieved 8 December Ear and labyrinth disorders.
It can also affect the central nervous system, causing psychotic reactions, nightmares and night sweats. The drug should be given before or with meals. It may also alter the effectiveness of combined oral contraceptive pills because of its effect on the gut flora. By binding to the 50s subunit of the bacterial rRNA complex, protein synthesis and subsequent structure and function processes critical for life or replication are inhibited.
Abnormal liver function tests may occur. It has been reported that erythromycin may aggravate the weakness of patients with myasthenia gravis.
Your name or email address: Matt Warner26 Apr Synthesis of an Erythronolide A Lactone System". Long-term management of asthma Accreditation Programme assesses the quality of the processes guidance producers use to develop their guidance. HayesLinda E.
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Diagnostic coronary angiography Accreditation Programme assesses the quality of the processes guidance producers use to develop their guidance. The capsules should be swallowed whole either before or with food; they should not be chewed. Webarchive template wayback links CS1 maint: Erythromycin is easily inactivated by gastric acid; therefore, all orally administered formulations are given as either enteric-coated or more-stable salts or esterssuch as erythromycin ethylsuccinate.
Another group of CYP3A4 substrates are drugs used for migraine such as ergotamine and dihydroergotamine ; their adverse effects may be more pronounced if erythromycin is associated. McCuistionJennifer J. If other CYP3A substrates — drugs that are broken down by CYP3A — such as simvastatin Zocorlovastatin Mevacoror atorvastatin Lipitor —are taken concomitantly with erythromycin, levels of the substrates increase, often causing adverse effects.