Linezolid PNU versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: Choice of Antibacterial Drugs. Zyvox linezolid injection, tablets, and oral suspension prescribing information.
Susceptibility testing of extensively drug-resistant and pre-extensively drug-resistant Mycobacterium tuberculosis against levofloxacin, linezolid, and amoxicillin-clavulanate. Time to peak concentrations is delayed and peak concentration decreased when administered with high-fat meal; 1 extent of absorption not affected.
Dosage adjustments not needed. In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis that are susceptible or resistant to first-line antituberculous drugs. Do not use linezolid in patients who are receiving or have received within the last 2 weeks an MAO inhibitor 1 see Serotonergic Drugs under Specific Drugs.
Pharmacokinetic, safety, and efficacy profiles similar to those in younger adults. Major Pharmaceuticals Camber Pharmaceuticals, Inc. Peak plasma concentrations attained within 1—2 hours following oral administration.
IDSA recommends 7—21 days of treatment. Not indicated for treatment of respiratory tract infections caused by gram-negative bacteria. Dosage reduction of antidiabetic agent or discontinuance of linezolid or antidiabetic agent may be necessary 1.
GI effects diarrhea, nausea, vomiting, localized or generalized abdominal pain, loose stoolsheadache, rash, dizziness, anemia, thrombocytopenia.
In vitro activity of linezolid against clinical isolates of Mycobacterium tuberculosis, including multidrug-resistant and extensively drug-resistant strains from Beijing, China. If peripheral or optic neuropathy occurs, weigh potential benefits versus risks of continued linezolid treatment. Advise patients that antibacterials including linezolid should only be used to treat bacterial infections and not used to treat viral infections e.
In vitro activities of dalbavancin and 12 other agents against aerobic and anaerobic gram-positive isolates recovered from diabetic foot infections. Importance of informing clinicians of existing or contemplated concomitant therapy including prescription drugs e. Bacteriostatic in vitro against susceptible enterococci and staphylococci; bactericidal against susceptible streptococci.
Serotonin syndrome after concomitant treatment with linezolid and citalopram. Not known whether linezolid or its metabolites removed by peritoneal dialysis. Importance of completing full course of therapy, even if feeling better after a few days. Zyvox linezolid injection, tablets, and oral suspension comprehensive review.
Am J Health-Syst Pharm.
Treatment with anti-infectives alters normal colon flora and may permit overgrowth of Clostridium difficile. In vitro activities of linezolid against important gram-positive bacterial pathogens including vancomycin-resistant enterococci.
It is imperative that an anti-infective active against gram-negative bacteria be used concomitantly if documented or presumptive pathogens also include gram-negative bacteria. Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.