Retrieved from " https: Resistance due to ribosomal methylation by erm -encoded enzymes in macrolides may also produce resistance to clindamycin. It is obtained by 7 S - chloro - substitution of the 7 R - hydroxyl group of lincomycin.
Antiparasitics — antiprotozoal agents — Chromalveolate antiparasitics P Topical clindamycin can be used for acne and intra-vaginally for treatment of bacterial vaginosis.
Getting clever with clindamycin -- an effective antibiotic in your toolbox
The clinical use of clindamycin is discussed separately in the appropriate topic reviews on specific infections. The spectrum of activity, pharmacology, and adverse effects of clindamycin will be reviewed here.
Clindamycin is an antibiotic useful for the treatment of a number of bacterial infections. When inducible, however, the isolate will test as resistant to erythromycin and susceptible to clindamycin.
Persistence of AMR genes can also arise from the transfer of genes between bacteria via mobile genetic elements, such as plasmids. Because of the high risk of CDAD, other antibiotics should be considered before using clindamycin. Pharmacy and Pharmacology portal.
An alternative method to investigate the diversity of AMR genes present in the microbiome is sequenced-based metagenomics using next-generation sequencing. Views Read Edit View history. J Antimicrob Chemother 65 Suppl 3: Clindamycinerythromycin, and azithromycin are available in oral and intravenous formulations, but little prospective, comparative data exist for their use in neonates.
Clindamycin is not a substrate for macrolide efflux pumps; so strains that are resistant to macrolides by this mechanism are susceptible to clindamycin.
CrossRef Medline Google Scholar. Food and Drug Administration for this purpose. All of the fecal anaerobes were identified as Bacteroidesone of the most abundant genera in the human gut 12 Retrieved Sep 4, Impact of antibiotic administration on isolate counts. Clindamycin is a chlorine-substituted derivative of lincomycinan antibiotic that is elaborated by Streptomyces lincolnensis.
Human intestinal bacteria as reservoirs for antibiotic resistance genes. Complicated urinary tract infections: Most strains of MSSA remain susceptible to clindamycin and erythromycin. For the fecal aerobes, at least one AMR gene was detected by microarray in of isolates, and in total 36 different genes were detected see Table S4 in the supplemental material.