According to the manufacturer of levofloxacin, coadministration should be avoided in patients taking other drugs that can result in prolongation of the QT interval. Other patient specific factors, such as fever, other disease states i. SA Public sector August — July tender. Major Monitor electrolytes and ECGs for QT prolongation if coadministration of levofloxacin with oxaliplatin is necessary; correct electrolyte abnormalities prior to administration of oxaliplatin.
Levofloxacin is indicated for the treatment of chronic bacterial prostatitis due to Escherichia coliEnterococcus faecalisor methicillin-susceptible Staphylococcus epidermidis [ see Clinical Studies Caution should be exercised when levofloxacin is coadministered with drugs that effect the tubular renal secretion such as probenecid and cimetidine, especially in renally impaired patients.
Streptomycin or gentamicin are the drugs of choice to treat plague in most patients. Efficacy studies of Levofloxacin could not be conducted in humans with pneumonic plague for ethical and feasibility reasons. Clinical response rates are summarized by pathogen for both groups in table 6.
Major Levofloxacin should be avoided in combination with Class IA antiarrhythmics disopyramide, procainamide, and quinidine. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. To evaluate the safety and efficacy of the higher dose and shorter course of Levofloxacin, outpatient and hospitalized adults with clinically and radiologically determined mild to severe community-acquired pneumonia were evaluated in a double-blind, randomized, prospective, multicenter study comparing Levofloxacin mg, IV or orally, every day for five days or Levofloxacin mg IV or orally, every day for 10 days.
Another published report evaluated the safety data collected from 2, children and adolescents who participated in 1 of 3 efficacy trials and were randomized to receive levofloxacin or nonquinolone antibiotics. Some fluoroquinolones, including Levofloxacin, have been associated with prolongation of the QT interval on the electrocardiogram and infrequent cases of arrhythmia.
Moderate to severe phototoxicity reactions have been observed in patients exposed to direct sunlight while receiving a systemic fluoroquinolone, such as levofloxacin. Moderate Careful monitoring of blood glucose is recommended when levofloxacin and antidiabetic agents, including the alpha-glucosidase inhibitors, are coadministered. Formulary Formulary Patient Discounts.
Call your doctor for medical advice about side effects. If you have any of the following serious side effects while you take Levofloxacin, you should stop taking Levofloxacin immediately and get medical help right away.
The breakpoints for levofloxacin relate to high dose therapy. Moderate The concomitant administration of quinolones and nonsteroidal antiinflammatory drugs has been reported to increase the risk of CNS stimulation and convulsive seizures.
Severe Concurrent use of levofloxacin and dronedarone is contraindicated. Although phototoxicity has occurred only rarely during levofloxacin therapy, patients should avoid excessive sunlight UV exposure. Dysglycaemia As with all quinolones, disturbances in blood glucose, including both hypoglycaemia and hyperglycaemia have been reported, usually in diabetic patients receiving concomitant treatment with an oral hypoglycaemic agent e. If you log out, you will be required to enter your username and password the next time you visit.
Levofloxacin is contraindicated in persons with known hypersensitivity to Levofloxacin, or other quinolone antibacterials [ see Warnings and Precautions 5.
Breakpoints apply to an oral dose of mg x 1 to mg x 2 and an intravenous dose of mg x 1 to mg x 2. Administration with Food, Fluids, and Concomitant Medications.