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Patients receiving theophylline who are maintained on hemodialysis should be closely monitored for bronchospasm during and after the hemodialysis procedure. How to cite this comment: Hemodialysis Clearance of Theophylline. Zwillich and co-workers 1 described eight patients in whom grand mal seizures developed during intravenous theophylline therapy, and of whom four died. Difference in reported hemodialysis clearance are probably related to the type of dialyser used.
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PY - Y1 - N2 - The hemodialysis clearance, total body clearance off dialysis, and protein binding for theophylline were determined in a year-old cigarette-smoking male in acute renal failure. Measurement of serum concentrations should be employed to facilitate dosage increases during hemodialysis.
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Abstract The hemodialysis clearance, total body clearance off dialysis, and protein binding for theophylline were determined in a year-old cigarette-smoking male in acute renal failure.
Decreased plasma protein binding may indicate the need for a lower therapeutic range in this patient population. Purchase access Subscribe to Learning for one year.